| VIDEO | AUDIO |
| OPEN ON A WIDE SHOT OF A LIVE RABBIT RESTING
ON A LAB TABLE. CUT TO DIFFERENT ANGLES OF THE RABBIT. |
SOUND: Begin music, mixed with natural sound from the lab
ANNCR: While association of pyrogenic reactions with the
intravenous injection of fluids is over 200 years old, it wasn't
until the turn of this century that scientists discovered they
could use our furry friend here to test for endotoxins. The
Rabbit Pyrogen Test was crude by today's standards, for
either the rabbit developed a fever or he didn't; positive or
negative - with no quantitative measuring. |
| CLOSE UP OF A HORSESHOE CRAB IN A TANK OF WATER. HANDS REACH IN AND TURN THE CRAB OVER. |
It wasn't until the 1960's that science turned to another animal
- the Horseshoe crab - to develop the more accurate limulus
amebocyte lysate test... a test that uses the arachnid's blood to
produce an extract which clots in the presence of gram-negative bacterial endotoxin. |
| WIDE SHOT OF LAB TECHNICIAN #1 USING THE QCL-1000. SHOW THE ASSAY STOPPING AND THE
TECHNICIAN STARTING IT AGAIN. |
In 1982, the L.A.L. test became truly quantitative when the
BioWhitaker Company introduced QCL-1000, the first
commercial endotoxin test to utilize a synthetic chromogenic
substrate. QCL-1000, however, required that the assay be
stopped, and had only a limited quantitative range. |
| WIDE SHOT OF TECHNICIAN #2, USING THE READER
AND MANUALLY TRANSFERRING SAMPLES. |
The next evolutionary step came shortly thereafter with the
development of a colyophilized L.A.L. / Chromogenic
substrate reagent, and an incubating microplate reader... a
reader that could monitor the progress of the assay, without
the need to stop it. BioWhitaker's Kinetic-QCL system also
combined the chromogenic L.A.L. assay with L.A.L. specific
software. But the Kinetic-L.A.L. assays were still labor
intensive, requiring manual preparation of the endotoxin
standards, manual dilution and transfer of the samples and
standards into the microplate, and manual spiking of the
positive product controls with endotoxin. |
| SHOW TECHNICIAN #3 WALKING INTO LAB. |
Recently, however, BioWhitaker scientists and engineers
raised the bar of Kinetic L.A.L. assays to its highest level
ever. How? By taking the word "manual" out of the L.A.L.
test. |
| HE STOPS IN FRONT OF THE AUTO L.A.L. ZOOM INTO CLOSE UP OF THE L.A.L., THEN ADD THE BIOWHITAKER LOGO. |
Introducing the Auto-L.A.L., the most recent entry in a long
list of technical innovations developed by BioWhitaker - the
recognized world leader in endotoxin detection systems and
reagents. During the next few minutes, you'll see the Auto-L.A.L. in action as we explain its one-of-a-kind features and
benefits. |
| CUT BACK TO A WIDE SHOT OF TECHNICIAN #3 AS HE BEGINS TO PREPARE THE ASSAY TEST. |
Designed to improve the detection of gram-negative bacterial
endotoxin, the Auto-L.A.L. was developed by combining
BioWhitaker's L.A.L. reagents with two instruments, and two
software programs to provide one seamless, automated
system. |
CLOSE UP OF THE WORK STATION.
CLOSE UP OF THE READER.
MEDIUM SHOT OF THE TECHNICIAN AT THE COMPUTER. |
It's a system that physically integrates two important
hardware elements: a Biomek 2000 biorobotic system and a
Biotech ELX808 incubating kinetic microplate reader. When
you couple this hardware with BioWhitaker's Proprietary
WIN-KQCL software and our custom modified operating
software, you have a time-saving, cost-effective system - a
platform that will provide you with automated pipetting,
diluting, dispensing, uniform plate heating, and unequaled
assay performance, all within a fixed and immobile
workstation. |
